VCU Human Genetics

Gordon Ginder

Gordon D. Ginder

Professor
Lipman chair in oncology
Director, Massey Cancer Center

Contact information
Office: Massey Cancer Center, Ground level, Room 107
P.O. Box: 980037
Phone: (804) 828-0450
Fax: (804) 828-5083
E-mail: gdginder@vcu.edu

Education

  • B.S. Biology and Chemistry (1971) University of Illinois, Urbana, Ill.
  • M.D. (1975) Johns Hopkins University, Baltimore, Md.
  • Internal Medicine Residency (1975-77) Case-Western Reserve University, Cleveland, Ohio

Professional experience

  • 1997 to present: Professor, internal medicine and human genetics, Virginia Commonwealth University, Richmond
  • 1997 to present: Director, Massey Cancer Center, VCU
  • 1990 to 1997: Director, medical oncology, University of Minnesota, Minneapolis
  • 1990 to 1997: Professor, medicine and human genetics, University of Minnesota, Minneapolis
  • 1989 to 1990: Professor, internal medicine and genetics, Internal Medicine, University of Iowa, Iowa City
  • 1985 to 1989: Associate professor, internal medicine and genetics, University of Iowa, Iowa City
  • 1983 to 1985: Assistant professor, Genetics Ph.D. Program, Internal Medicine, University of Iowa, Iowa City
  • 1981 to 1985: Assistant professor, hematology/oncology, Internal Medicine, University of Iowa, Iowa City
  • 1979 to 1981: Fellow-associate, hematology/oncology, Internal Medicine, University of Iowa, Iowa City
  • 1977 to 1979: Research associate, Laboratory of Molecular Biology, Gary Felsenfeld, supervisor, NIAMDD/NIH
  • 1975 to 1977: Resident, Internal Medicine, Case-Western Reserve University, Cleveland, Ohio
  • 1971 to 1975: National Institutes of Health predoctoral trainee (18 mos. full-time lab), Haig H. Kazazian, supervisor, Johns Hopkins University, Baltimore, Md.

Honors

  • Alpha Omega Alpha – Johns Hopkins
  • Henry Strong Dennison Research Award – Johns Hopkins
  • American Society of Clinical Investigation
  • 2003: Scientist of the Year from Science Museum of Virginia
  • 2002: W. Robert Irby Award for Philanthropic Leadership from MCV Foundation
  • 2000: American Association of Physicians
  • 1997 to present: Editorial Board, Blood
  • 1995: President, National Blood Club
  • 1992 to 2000 NIH MERIT Award
  • 1987 to 1992: Established Investigator Award – American Heart Association
  • 1987 to 1990: VA MERIT Review Board in Hematology
  • 1984 to 1987: Clinical Investigator Award – Veterans Administration

Funded research

  • P30CA016059: Cancer Center Core Support
  • R01CA087496: Regulation of Class I Gene Expressions in Tumor Cells
  • R01DK029902: Globin Gene Regulation During Erythroid Differentation
  • P01HL055552: Globin Gene
  • T32CA085159: Postdoctoral Training Program in Cancer Biology

Research interests

  • Globin Gene Regulation During Erythroid Differentiation
  • Interferon Regulation of Class I Gene Expression in Human Tumors

Publications (partial listing)

  • Singal R, Wang SZ, Sargent T, Zhu SZ, Ginder GD (2002) Methylation of promoter proximal- transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex. J Biol Chem 277(3):1897-1905
  • Snyder SR, Waring JF, Zhu SZ, Kaplan S, Schultz J, Ginder GD (2001) A 3'-Transcribed Region of the HLA-A2 Gene Mediates Post-transcriptional Stimulation by IFN-É¡. J of Immunol 166:3966-3874
  • Snyder SR, Wang J, Waring JF, Ginder GD (2001) Identification of CCAAT displacement protein (CDp/cut) as a locus-specific repressor of major histocompatibility complex gene expression in human tumor cells. J Biol Chem 276(7):5323-5330
  • Singal R, Tu ZJ, Vanwert JM, Ginder GD, Kiang DT (2000) Modulation of the connexin26 tumor suppressor gene expression through methylation in human mammary epithelial cell lines. Anticancer Res 20(1A):59-64
  • Singal R and Ginder GD (1999) DNA methylation. Blood 93:4059-4070
  • Osborne CS, Pasceri P, Singal R, Sukonnik T, Ginder GD, Ellis J (1999) Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells. J Virol 73:5490-5496
  • Olivieri NF, Rees DC, Ginder GD, Thein SL, Waye JS, Chang L, Brittenham GM, Weatherall DJ (1998) Elimination of transfusions through induction of fetal hemoglobin synthesis in Cooley's anemia. Ann NY Acad Sci 850:100-109
  • Ginder GD, Singal R, Little JA, Dempsey N, Ferris R, Wang SZ (1998) Silencing and activation of embryonic globin gene expression. Ann NY Acad Sci 850:70-79
  • Singal R, Ferris R, Little JA, Wang SZ, Ginder GD (1997) Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells. Proc Natl Acad Sci USA 94:13724-13729
  • Olivieri NF, Rees DC, Ginder GD, Thein SL, Brittenham GM, Waye JS, Weatherall DJ (1997) Treatment of thalassaemia major with phenylbutyrate and hydroxyurea [letter]. Lancet 350:491-492
  • Ginder GD, Kennedy BJ (1997) Impact of technology change and managed care on medical oncology. J Cancer Educ 12:73-76
  • Wandersee NJ, Ferris RC, Ginder GD (1996) Intronic and flanking sequences are required to silence enhancement of an embryonic beta-type globin gene. Mol Cell Biol 16:236-246
  • Gustafson KS, Ginder GD (1996) Interferon-gamma induction of the human leukocyte antigen-E gene is mediated through binding of a complex containing STAT1alpha to a distinct interferon-gamma-responsive element. J Biol Chem 271:20035-20046
  • Waring JF, Radford JE, Burns LJ, Ginder GD (1995) The human leukocyte antigen A2 interferon-stimulated response element consensus sequence binds a nuclear factor required for constitutive expression. J Biol Chem 270:12276-12285
  • Sher GD, Ginder GD, Little J, Yang S, Dover GJ, Olivieri NF (1995) Extended therapy with intravenous arginine butyrate in patients with beta-hemoglobinopathies. N Engl J Med 332:1606-1610
  • Little JA, Dempsey NJ, Tuchman M, Ginder GD (1995) Metabolic persistence of fetal hemoglobin. Blood 85:1712-1718
  • Snyder SR, Waring JH, Ginder GD (1994) Identification of nucleolin as a potential activator of human class I major histocompatibility complex gene transcription. Blood 84:203a
  • Perrine SP, Olivieri NF, Faller DV, Vichinsky EP, Dover GJ, Ginder GD (1994) Butyrate derivatives. New agents for stimulating fetal globin production in the beta-globin disorders. Am J Pediatr Hematol Oncol 16:67-71
  • Radford JEJ, Waring JF, Pohlman JK, Ginder GD (1993) Stimulation of MHC class I transcription by interferon-gamma involves a non-A, non-C kinase in addition to protein kinase C. J Interferon Res 13:133-141
  • Burns LJ, Waring JF, Reuter JJ, Stinski MF, Ginder GD (1993) Only the HLA class I gene minimal promoter elements are required for transactivation by human cytomegalovirus immediate early genes. Blood 81:1558-1566
  • Radford JEJ, Chen E, Hromas R, Ginder GD (1991) Cell-type specificity of interferon-gamma-mediated HLA class I gene transcription in human hematopoietic tumor cells. Blood 77:2008-2015
  • Glauber JG Wandersee NJ, Little JA, Ginder GD (1991) 5'-flanking sequences mediate butyrate stimulation of embryonic globin gene expression in adult erythroid cells. Mol Cell Biol 11:4690-4697
  • Glauber JG Little JA, Ginder GD (1991) Butyrate induced alteration in developmental globin gene regulation. In: G Stamatoyannopoulos (ed.), The Regulation of Hemoglobin Switching, pp. 413-424, Baltimore: The Johns Hopkins University Press.
  • Ginder GD (1991) Analysis of DNA methylation and Dnase I sensitivity in gene-specific regions of chromatin. In: EJ Benz, Jr. (ed.), Molecular Genetics, pp. 413-424, Baltimore: The Johns Hopkins University Press.
  • Zenk DW, Ginder GD, Brotherton TW (1990) A nuclear matrix protein binds very tightly to DNA in the avian beta-globin gene enhancer. Biochem 29:5221-5226
  • Brotherton TW, Reneker J, Ginder GD (1990) Binding of HMG 17 to mononucleosomes of the avian beta-globin gene cluster in erythroid and non-erythroid cells. Nucleic Acids Res 18:2011-2016
  • Ginder GD (1989) Determination of methylation and Dnase I sensitivity in regions of specified genes. In: Anonymous Methods in Hematology, pp. 111-123, New York: Churchill-Livingston.
  • Ginder GD, Burns LJ, Glauber JG and Beck J (1989) Pharmacologic induction of embryonic globin gene expression in adult avian erythroid cells. Prog Clin Biol Res 316B:327-339
  • Brotherton TW, Jagannadham MV, Ginder GD (1989) Heparin binds to intact mononucleosomes and induces a novel unfolded structure. Biochem 28 :3518-3525
  • Brotherton TW, Zenk DW, Bennett JP, Ginder GD (1989) Topoisomerase II activity is not involved in the maintenance of active b-globin chromatin structure in avian reticulocytes. Prog Clin Biol Res 316:57-67
  • Bennett JP, Brotherton TW, Ginder GD (1989) Nuclear matrix attachment regions of the chicken beta-type globin gene cluster. Prog Clin Biol Res 316B:47-55
  • Burns LJ, Glauber JG, Ginder GD (1988) Butyrate induces selective transcriptional activation of a hypomethylated embryonic globin gene in adult erythroid cells. Blood 72:1536-1542
  • Chen E, Karr RW, Ginder GD (1987) Negative and positive regulation of human leukocyte antigen class I gene transcription in K562 leukemia cells. Mol Cell Biol 7:4572-4575
  • Chen E, Karr RW, Frost JP, Gonwa TA, Ginder GD (1986) Gamma interferon and 5-azacytidine cause transcriptional elevation of class I major histocompatibility complex gene expression in K562 leukemia cells in the absence of differentiation. Mol Cell Biol 6:1698-1705 35.
  • Ginder GD, Whitters MJ, Pohlman JK (1984) Activation of a chicken embryonic globin gene in adult erythroid cells by 5-azacytidine and sodium butyrate. Proc Natl Acad Sci USA 81:3954-3958